In regard to the role of MCT4 in cancers, Wang et al. demonstrated that CD147-K234me2 can promote MCT4 translocation from the cytoplasm to the plasma membrane to enhance lactate export and thereby, lead to exacerbated progression and shortened overall survival of NSCLC [206], suggesting that the abundant expression of MCT4 is highly associated with the poor prognosis of cancer. The gene discussed is SLC16A3; the disease is cancer.