SIRT5 and colorectal cancer: For example, sirtuin 5 (SIRT5) can deacetylate LDHB at lysine 329 to accelerate the growth of colorectal cancer [149], and the increased phosphorylation of LDHB at serine 162 can promote NAD+ regeneration, glycolytic flux, lactate production, and glycolytic intermediate generation [150].