For example, lactate can stimulate the nuclear factor kappa B (NF-κB)/ Interleukin-8 (IL-8) or the HIF-1α signaling pathway to promote tumor angiogenesis and growth when it is released from tumor cells through MCT4 and imported into endothelial cells via the MCT1 [197,198]. This evidence concerns the gene CXCL8 and neoplasm.