SLC16A3 and non-small cell lung carcinoma: In regard to the role of MCT4 in cancers, Wang et al. demonstrated that CD147-K234me2 can promote MCT4 translocation from the cytoplasm to the plasma membrane to enhance lactate export and thereby, lead to exacerbated progression and shortened overall survival of NSCLC [206], suggesting that the abundant expression of MCT4 is highly associated with the poor prognosis of cancer.