PDK1 and pancreatic neoplasm: In the mouse model of pancreatic cancer, the activities of glycolytic metabolic-related enzymes (HK, PGK, pyruvate dehydrogenase kinase (PDK1), and LDHA) and the lactate transporter of MCT4 are far higher in the pancreatic tumor than the normal tissue [94], implying the potential role of lactate in tumor pathology.