Tumors can eventually overcome antitumor immunity through mechanisms already mentioned, including tumor antigen editing, loss of MHC I expression, and expression of immune inhibitors such as PD-L1 [141,142,143] or suppressive mediators such as IL-10 [144], TGF-β [145], and TRAIL decoy receptors [146,147]. The gene discussed is IL10; the disease is neoplasm.