TIMP3 and melanoma: It was reported that exosome-derived miR-21 from B16F10 cells can induce fibroblasts to be more invasive with down-regulation of tissue inhibitor of metalloproteinase 3 (TIMP3) expression and up-regulation of matrix metalloprotein (MMP) expression, which rearrange extracellular matrix (ECM) to facilitate melanoma cells migration and invasion [48].