Additionally, miR-222 was shown as a key factor for melanoma development and dissemination, not only because of its down-modulation of several direct targets, such as cyclin-dependent kinase inhibitor 1B (p27Kip1/CDKN1B), KIT proto-oncogene (c-KIT) receptor, and Fos proto-oncogene (c-FOS), but also due to its delivery through exosomes into surrounding low metastatic melanoma cells to improve their migration and invasion ability [41]. This evidence concerns the gene CDKN1B and melanoma.