For example, reduced exosomal miR-1180-3p in melanoma patient plasma is indicated as a promising diagnostic marker of melanoma, and the level of miR-1180-3p was also verified lower in melanoma cell line than that in melanocytes and negatively associated with melanoma proliferation, migration, and invasion by targeting ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4) [96]. Here, ST3GAL4 is linked to melanoma.