In addition, it was identified that P2X7 receptor (P2X7R) stimulation triggers melanoma cells to release microvesicles and exosomes, and also induces a change in the miRNA composition such as miR-495-3p, miR-376c-3p, and miR-6730-3p, which are strongly upregulated in all vesicles subtypes and contribute to melanoma growth and metastasis [45]. Here, P2RX7 is linked to melanoma.