Further study indicated that reduction of TNF-α is associated with hsa-miR-181 family, hsa-miR-122, hsa-miR-149, hsa-miR-498, and hsa-miR-3187-3p enriched in melanoma-derived exosomes, especially hsa-miR-181 family and hsa-miR-498 interact directly with the 3′-UTR sequence of TNF-α. Here, TNF is linked to melanoma.