Interestingly, miR-2478 derived from milk exosomes can inhibit the expression of RAS-related protein 1a (RAP1A) in melanoma cells, thereby promoting the activation of protein kinase B (AKT) and inactivation of glycogen synthase kinase 3 beta (GSK3β), and ultimately leading to the inhibition of microphthalmia-associated transcription factor (MITF) expression [47]. The gene discussed is GSK3B; the disease is melanoma.