Moreover, CD45, a crucial regulator for successful antigen receptor signaling in T cells [78], was also downregulated on CD8+ T cells after uptake of melanoma-derived exosomes, which is mediated by carried hsa-miR-3187-3p through directly targeting protein tyrosine phosphatase receptor type C (PTPRC) 3′-UTR. This evidence concerns the gene PTPRC and melanoma.