KEGG pathway enrichment analysis revealed that the 15 hub genes were significantly involved in the “FoxO signaling pathway” (hsa04068), “ErbB signaling pathway” (hsa04012), “HIF-1 signaling pathway” (hsa04066), “Ferroptosis” (hsa04216), and “Acute myeloid leukemia” (hsa05221). The gene discussed is HIF1A; the disease is acute myeloid leukemia.