SNX2 was the first member of the SNX family to be reported in acute myeloid leukemia (AML) by the group of Fuchs et al. With the help of screening a human kidney library, this group identified SNX2 as an interacting partner of the formin-binding protein 17 (FBP17), a known MLL-fusion protein found in AML patients [121]. The gene discussed is KMT2A; the disease is acute myeloid leukemia.