Pim-2 kinase, a member of the Pim family constituting a class of serine/threonine kinases [1], is encoded by the oncogene Pim-2, located on the X chromosome [2], and is highly expressed in multiple cancers, including most hematological malignancies (leukemia, myeloma, and lymphoma) and some solid tumors (liver, lung, prostate, and breast cancers) [3,4,5]. This evidence concerns the gene PIM2 and plasma cell myeloma.