This later report also described overall reduced B-cell counts in blood among MBLlo subjects, mostly at the expense of the immature and naïve B-cell populations; however, for the CD8+ T-cell counts, these differences did not stand after correction by age [22], concurring with previous findings of our group in a more limited cohort of donors (27 CLL-like MBLlo vs. 40 non-MBL HD) [23] and the results reported here. This evidence concerns the gene CD8A and B-cell chronic lymphocytic leukemia.