It is observed that miR-221 downregulates the action of TGF-β, on the aberrant airway smooth muscle proliferation and size, and consequently proinflammatory effects [61]; miR-28–5p and miR-146a/b downregulation led to circulating CD8+ T-cell activation in severe asthma [62]; and miR-223–3p, miR-142–3p, and miR-629–3p are well correlated with neutrophils in severe asthma [63]. The gene discussed is TGFB1; the disease is asthma.