miR-320a-3p, miR-210-3p, miR-92a-3p, miR-21-5p, and miR-140-3p compared to of surfactant protein B (Pro-SFTPB), cancer antigen 125 (CA125), carcinoembryonic antigen (CEA), and cytokeratin-19 fragment (CYFRA21-1) precursor forms improved sensitivity at statistical analysis to detect the condition of LC diseases. This evidence concerns the gene CEACAM5 and laryngotracheoesophageal cleft.