Mechanistic aspects of the role of NaV1.5 channels in colon cancer have been previously addressed by the exploration of in vitro models, human biopsies and bioinformatics analyses demonstrating that these channels are key regulators of a transcriptional network of genes controlling invasion, which includes MAPK signaling via ERK phosphorylation and the PKA/ERK/c-JUN/ELK-1/ETS-1 transcriptional pathway [18,20]. This evidence concerns the gene ELK1 and malignant colon neoplasm.