Previous evidence has shown a regulation of the internal and perimembrane pH via the inhibition of NaV1.5 activity with TTX [14], and shortly thereafter a colocalization of NaV1.5 sodium channels and NHE-1 exchanger in regions rich in Caveolin-1 at the plasma membrane of breast cancer cells was found [15]. The gene discussed is SCN5A; the disease is breast cancer.