Previous evidence has shown a regulation of the internal and perimembrane pH via the inhibition of NaV1.5 activity with TTX [14], and shortly thereafter a colocalization of NaV1.5 sodium channels and NHE-1 exchanger in regions rich in Caveolin-1 at the plasma membrane of breast cancer cells was found [15]. This evidence concerns the gene SCN5A and breast carcinoma.