SCN5A and colonic neoplasm: Finally, we assessed the 2D invasiveness of colon cancer cells under the pharmacological inhibition of NaV1.5 channels using TTX, of NHE exchangers using EIPA, in cells transfected with irrelevant small interfering RNA (siCTL), or targeted to SCN5A (siSCN5A) or SLC9A1 (siSLC9A1).