Furthermore, these proteins were not only identified to colocalize at the plasma membrane of cancer cells but their direct interaction was also demonstrated by proximity ligation assays at the highly specialized invadopodial membrane structures, which together with the proteases cathepsin-B and membrane-type 1 matrix metalloproteinase (MT1-MMP) generate sites of degradation of extracellular matrix [16]. Here, MMP14 is linked to cancer.