In order to identify the IC50 of each compound on NaV1.5 channels expressed in SW620 colon cancer cells, we tested the effect of increasing concentrations of the compounds named compound 1 and compound 4 on the peak Na+ currents evoked by step depolarization at −5 mV from an HP of −100 mV applied every 2 s. Here, SCN5A is linked to colonic neoplasm.