LGALS3 and malignant colon neoplasm: Particularly, it has been demonstrated that Gal-3 overexpression increases the migration of colon cancer cells through the activation of the K-Ras–Raf–Erk1/2 pathway [79] and that its interaction with extracellular carcinoembryonic antigen (CEA) promotes the migration of cancer cells and the appearance of distal metastases.