In addition to the direct effects on colon cancer cells, Gal-3 regulates immune cell function in both innate and adaptive responses, where it participates in the activation or differentiation of many immunocompetent and inflammatory cells, including neutrophils, monocytes/macrophages, eosinophils, mast and dendritic cells (DCs) and activated T and B cells. This evidence concerns the gene LGALS3 and colonic neoplasm.