Gal-3 serum concentration was also examined in patients with untreated CRC in association with interleukin (IL-10, IL-12 and IL-17) production, lymphocyte activation and inflammatory parameters, such as neutrophil/lymphocyte ratio (NLR), white blood cell count (WBC) and C-reactive protein (CRP) [96]. This evidence concerns the gene LGALS3 and colorectal carcinoma.