HGF and osteosarcoma: Previous studies revealed that inhibitory effects on cell migration and invasion activity in human renal carcinoma cells [24], osteosarcoma cells [19], NSCLC cells [15] and TSAIII inhibits HGF to induce metastatic activity in MDA-MB-231 cells [18] were not due to TSAIII cytotoxicity in the dosage range from 2 to 6 μM.