Consistent with this finding, inhibition of kinases involved in the G2 checkpoint, such as aurora kinase A (AURKA) [12], aurora kinase B (AURKB) [13,14], and checkpoint kinase 1 (Chk1) [15], has induced mitotic catastrophe and p53-independent cell death in TP53 mutant cancer cells. This evidence concerns the gene TP53 and cancer.