HMGB1 and cancer: Studies have reported that when cancer cells are induced to undergo pyroptosis through specific means, immunogenic substance damage-associated molecular patterns (DMAPs), such as high-mobility group box 1 (HMGB1), calreticulin, and ATP, can be released to turn “cold” tumors into “hot” tumors, so as to improve immune efficacy, which is a good anticancer strategy [12].