For example, Chen et al. designed a GSH-responsive nanogel (LD NP) coloaded with LAQ824 (a typical HDACI) and DOX, which can release the two drugs in the tumor microenvironment, activate caspase-3 to mediate pyroptosis induced by GSDME, and, thus, promote antitumor immunity [51]. Here, CASP3 is linked to neoplasm.