NR4A1 and colorectal carcinoma: Here, we show for the first time that CK directly binds Nur77 to suppress Nur77-mediated stemness and metastasis in vitro and in vivo via disrupting Nur77-Akt feed-forward signaling under a hypoxic microenvironment, revealing a new target and novel mechanism of action for CK for the treatment of metastatic CRC.