In NB, a subset of αFAP and FSP-1 expressing CAFs share characteristics and pro-tumorigenic activity with mesenchymal stromal cells, therefore they have been termed CAF-MSCs [19,20], and their pro-tumorigenic potential in NB progression has been confirmed by different groups [8,14,19,20,21,22,23,24,25]. The gene discussed is AFAP1; the disease is neuroblastoma.