It is a multikinase inhibitor targeting VEGFR1-3, MET, the TAM family of kinases (TYRO-3, AXL, MER), RET, ROS1, KIT, TRKB, FLT-3, and TIE-2, which are mostly involved in tumor growth, angiogenesis, and immune regulation [14,348,370]. The gene discussed is RET; the disease is neoplasm.