RYR2 and metabolic dysfunction-associated steatohepatitis: Liang et al. identified 82 genes to be recurrently mutated in two or more NASH-HCCs; which included two genes mutated in 4/5 NASH-HCCs (Ryr1 and Sdk1), 8 genes mutated in 3/5 NASH-HCCs (Epha8, Pcdh15, Fat2, Cep152, Ttn, Rxfp1, Aox3l1, and Pkd1l3), and 71 genes mutated in 2/5 NASH-HCCs (notably Mtor, Ryr2, Cacna1h, Col7a1, Fcgbp, Adam29, Gpr98, and Pclo) [100].