Sterile inflammation occurs in the absence of pathogens, and is activated during NASH disease due to damage-associated molecular patterns (DAMPs) are released from damaged cells (e.g., nuclear and mitochondrial DNA, uric acid, and purine nucleotides), causing the maturation and secretion of both interleukin (IL)-1β and IL-8, thus sustaining inflammation [151,175]. Here, CXCL8 is linked to metabolic dysfunction-associated steatohepatitis.