Moreover, activation of the mTORC1/4E-BP1/S6K/SREBP1 cascades via GSK3 phosphorylation and the components of the STAT3-AR-CCRK-mTORC1 pathway are concordantly overexpressed in human NASH-associated HCCs [103]. The gene discussed is AR; the disease is metabolic dysfunction-associated steatohepatitis.