MACROH2A1 and cancer: It has been shown that macroH2A1 knockdown cell lines acquire cancer stem cells features, such as enhancement of the tumorigenic potential, slow proliferation, resistance to chemotherapy treatments, elevating in mRNA expression of reprogramming genes, and augmented glycolysis, reflecting the same phenotype of human undifferentiated and aggressive HCCs, which express a low level of macroH2A1 [298].