Moreover, in human NASH-HCCs, most of the genes mutated (11/19) encoded calcium channels proteins (RYR1, RYR2, CACNA1B, CACNA1E, CACNA1H, CACNA1I, GRIN2C, ATP2A2, ATP2B4, SLC8A1, and ITPR3). This evidence concerns the gene RYR1 and metabolic dysfunction-associated steatohepatitis.