To investigate the signaling networks with mutations in NASH-HCCs, Liang et al. conducted KEGG pathway analysis; and they found seven pathways significantly enriched by gene mutations in three or more NASH-HCCs, which include metabolic, insulin and calcium signaling, cell adhesion and tight junction molecules, ABC transporters, and axon guidance [100]. The gene discussed is ABCG2; the disease is metabolic dysfunction-associated steatohepatitis.