In addition, Desterke and Chiappini identified genes implicated in the progression of NASH to HCC, which include genes involved in the regulation of fatty acid and cholesterol metabolisms such as LPL, VLDLR, LIPA, ANXA2, and PLEK; lipid accumulation (CIDEC, PLIN1); and metabolism (PPARA and BCL2A1). The gene discussed is ANXA2; the disease is metabolic dysfunction-associated steatohepatitis.