NLRP3 and metabolic dysfunction-associated steatohepatitis: Hepatocyte-specific Xbp1 deficiency inhibited the development of NASH in mice diets, and Xbp1-deleted macrophages reduced steatohepatitis by decreasing the expression of nucleotide-binding domain leucine-rich repeat-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) and secretion of pro-inflammatory cytokines [106].