The TM6SF2 rs5854026 C/T polymorphism results in the replacement of glutamate with a lysine in the residue 167 (E167K), and this variant is susceptible to NASH progressive forms due to a higher degree of steatosis, inflammation, and fibrosis, but is protected against cardiovascular disease [72]. The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatohepatitis.