MTTP and fatty liver disease: In summary, hepatic steatosis is associated with defects in intrahepatic lipolysis (e.g., decreased ATGL/CGI-58 activity), defects in triglyceride export (e.g., defective Apo-B 100, MTTP activity), augmented glucokinase activity resulting in elevated hepatic DNL, and reductions in hepatic mitochondrial/peroxisomal β-oxidation [245].