TSC2 and hepatocellular carcinoma: The most frequently mutated genes in HCC cases were reported by the Cancer Genome Atlas (TCGA) Research Network, including the TERT promoter, TP53, and CTNNB1 [96]; and along with low-frequency mutated genes (e.g., AXIN1, ARID1A, ARID2 and RB1, BAP1, NFE2L2, KEAP1, TSC1/TSC2, MLL2, ALB (Albumin), and APOB mutations), help define some of the core deregulated pathways in HCC [97].