The enzymes included in glycolysis (e.g., HK2 and pyruvate kinase M2, PKM2) are highly expressed in HCC and tumor cells, leading to Warburg effect [6,231], due to the energy demand for rapid cell multiplication, tumor cells catabolize glucose into lactate through glycolysis, despite the availability of oxygen for aerobic metabolism (mitochondrial oxidative phosphorylation), tumor cells need the energy for the synthesis of nucleic acids, proteins, and lipids as components of the new transformed cells [232]. This evidence concerns the gene HK2 and neoplasm.