CD274 and neoplasm: However, there are instances in which RT-induced immune mechanisms contribute to immune suppression through the upregulation of PDL-1 in tumor and immune cells by the recruitment of suppressive cells and through the induction of the secretion of proinflammatory cytokines and chemokines such as transforming growth factor β (TGFβ), chemokine CC motif ligand 2 (CCL2) or colony-stimulating factor 1 (CSF-1), among others by stromal cells [6,7,8].