CACNA2D2 and cerebellar ataxia: This pattern is evident in the other common conserved genes: RIMBP3, associated with manchette function and spermiogenesis [30], HTT, mutated in Huntingtin’s disease [31] (although a reduced incidence of cancer is reported in Huntingtin’s disease [32]), CACNA2D, associated with Parkinson’s disease [33], and VPS13D, associated with ataxia [34] with a possible role in mitochondrial fission and peroxisome biogenesis [30,35].