We use differences in patterns of Darwinian selection for critical genes in mutant EGFR (EGFR-mut), mutant KRAS (KRAS-mut), and non-EGFR/KRAS (NEK) lung cancers to identify variations in their evolutionary arcs and associated co-adaptations that govern their molecular characteristics [1,2,3]. Here, EGFR is linked to lung carcinoma.