The DCIS eradication rate was significantly greater in HER2-positive disease (Chi-square statistic with Yates correction 17.8, p = 0.00003) and TNBC treated with NACT (Chi-square statistic with Yates correction 12.2, p = 0.0005), compared to ER-positive DCIS treated with NET. The gene discussed is ERBB2; the disease is ductal breast carcinoma in situ.