Cholesterol metabolism appears to be very important for highly proliferative tumor cells, as demonstrated by the deregulation of the transcription factors sterol regulatory element-binding protein 1 (SREBP-1), the upregulation of which promotes HCC growth and metastasis [70], and liver X receptor (LXR), which regulates both cholesterol homeostasis and lipogenesis and was found to be downregulated in HCC tissues [38,71]. Here, SREBF1 is linked to hepatocellular carcinoma.