TFRC and hepatocellular carcinoma: Examining the clinicopathological data of HCC samples, the authors also linked the increased expression of TFRC with high vascular invasion and tumor histological grade, and they reported a correlation between FLVCR1-augmented expression and higher tumor stage, tissue inflammation, vascular invasion and tumor histological grade, suggesting the potential role of TfR1 and FLVCR1 in HCC pathogenesis [91].