ACADM and hepatocellular carcinoma: In line with the high content of FAs, several enzymes with a role in the FAO pathway are dysregulated in HCC, such as the rate-limiting enzyme carnitine palmitoyl transferase 1 (CPT1) and other lipolysis-related enzymes that are upregulated in HCC, as well as medium/long-chain acyl-CoA dehydrogenase (MCAD/LCAD), which is downregulated in HCC [38].