FBXL5 and hepatocellular carcinoma: It has also been shown that iron-sensing ubiquitin ligase FBXL5, a previously unrecognized oncosuppressor in liver carcinogenesis in mice, and dysregulation of FBXL5-mediated cellular iron homeostasis are associated with poor prognosis in human HCC, suggesting that FBXL5 plays a key role in defense against hepatocarcinogenesis.