Recently, Chen et al. confirmed the reprogramming of glycolytic metabolism in HCC CSCs, which showed an overexpression of glycolysis-related genes (e.g., genes encoding for GLUT1, HK2, PFK liver type (PFKL) and LDH-A), together with a downregulation of OXPHOS-related genes (e.g., cytochrome B (CytB), as well as ATP synthase membrane subunit 6 and 8 (ATP 6 and 8) genes]. This evidence concerns the gene HK2 and hepatocellular carcinoma.