Although most caspases are constitutively expressed and predominantly regulated through activation of their inactive zymogens, we previously reported on the inhibition of the pro-apoptotic caspase-2 at the level of translation by the ubiquitin E3 ligase tri-partite motif-containing protein 25 (TRIM25) as a novel cell survival mechanism in human colon carcinoma cells [6]. This evidence concerns the gene CASP2 and colon carcinoma.