A clear and significant increase in caspase-7 protein after different time periods of TRIM25 silencing was confirmed in four different human colon carcinoma cell lines, including RKO (Figure 1B), HCT-15 (Figure 1C), DLD-1, CaCo-2 and also in HEK293 cells (Supplementary Figure S1A,B), indicating that the inverse correlation of both proteins is not a tumor-specific phenomenon. The gene discussed is CASP7; the disease is neoplasm.