NLRC4 and infection: There also appears to be some contradictory reports regarding the impact of T3SS-triggered inflammatory responses on the outcome of infection, in that the same inflammasome (NLRC4) has been shown to be either crucial in P. aeruginosa clearance, thus benefiting the host; or paradoxically facilitating bacterial colonization and enhancing P. aeruginosa pathogenesis, thus benefiting the pathogen.