Having flagella is beneficial in increasing dissemination and enhancing infection; however, flagella can also be a source of vulnerability for P. aeruginosa, as monomeric flagellin detection by Toll-like receptor 5 (TLR5) has been shown to trigger robust inflammatory responses in various immune leukocytes, resulting in diminished bacterial survival in an acute lung infection model [207,208]. This evidence concerns the gene TLR5 and infection.