An oligonucleotide microarray analysis-based study found that NUCB1 was up-regulated during the transformation from a low-grade NHL (FL) to a high-grade NHL (DLBCL) [97] with an inferior 5-year relative survival rate [102]; therefore, the elevation of NUCB1 can indicate poor prognosis in this setting. Here, NUCB1 is linked to non-Hodgkin lymphoma.