The three most frequent groups of genetic mutations and rearrangements in DLBCL are (1) mutations in genes that are necessary for GC reactions (MYC, BCL2, and BCL6), (2) mutations in genes related to DNA, epigenetic factors, and posttranslational modification (PTM) of histones (EZH2, DICER1, CREBBP, and MLL2) [36], and (3) rearrangements involving the MYC, BCL2 and/or BCL6 genes [37]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.