In this study, the decrease was selective, as indicated because the levels of the other isoforms, LAMP-2B and LAMP-2C, were not affected and because the change was accompanied by a decrease in the level of the chaperone hsc70 and an increase in the level of α-synuclein, revealing CMA impairment associated with PD [172]. This evidence concerns the gene HSPA8 and Parkinson disease.