With relevance to this review, a meaningful number of PD-associated genes, including GBA, LRRK2, ATP13A2, TMEM175, VPS35, ATP6P2, RAB7L1, VPS13C, DNALC13, DNAJC6, PINK1, PRKN, UCHL-1 and CTSD are involved in the autophagy–lysosome–endosomal system [25]. This evidence concerns the gene PRKN and Parkinson disease.