CALR and cancer: The GSEA revealed that the most altered biological processes and hallmarks in both type 1 and type 2-like calreticulin-mutated nematodes (Table S7) were distinguishing signatures of cancer [15] that participate in the pathogenesis of MPNs, such as the activation of the cell cycle, DNA repair mechanisms, and Wnt and Notch signaling, or the dysregulation of cellular metabolism (Figure 2).