CYBB and acute respiratory distress syndrome: Table 3 summarizes the effects of different models/treatments on PRDX6 enzyme activity and lung injury. It is worth noting that NOX2 immunity of the host is essential. In neutrophils and macrophages, ROS produced by NOX2 can directly kill pathogenic microorganisms on the one hand and activate many immune signal transduction pathways on the other hand [85]. In cecal-ligation-and-puncture-induced ALI, the number of bacteria in the lungs and peritoneal fluid of mice treated with PIP-2 alone increased, which was reversed with antibiotics [86].