To gain a possible clinical connection of GLUT1 (encoded by the SLC2A1 gene) and PKM2 (encoded by the PKM2 gene) to OSCC, we assessed both gene expression in the head and neck squamous cell carcinoma (HNSCC) database of the Cancer Genome Atlas (TCGA) project through the UALCAN web portal [22]. The gene discussed is PKM; the disease is head and neck squamous cell carcinoma.