FDX2 and lung carcinoma: Since cuproptosis is a death-related process, we therefore hypothesize that this phenomenon may have two possible explanations: first, the physiological level of cuproptosis is very low so that manipulation of FDX1 has negligible effect on this type of cell death; second, FDX2, another Fe-S cluster protein, may replace FDX1 to play a major role in regulating cuproptosis in lung cancer cells.