PDHB and nonpapillary renal cell carcinoma: As shown in Figure 1A, the expression levels of 5/7 positive regulators of cuproptosis (FDX1, DLD, DLAT, PDHB, and PDHA1) were robustly decreased in ccRCC as compared to normal kidney controls, whereas the negative regulator CDKN2A was profoundly increased in ccRCC patients as compared to the adjacent non-cancerous tissues, suggesting that the carcinogenesis of ccRCC selectively suppresses physiological cuproptosis signaling.