VEGFC and psoriasis: In two psoriasis-like skin inflammation models, an oxazolone-mediated contact hypersensitivity (CHS) model in mice overexpressing VEGF-A in the epidermis [14] and the repeated application of imiquimod in wild-type mice [15], we demonstrated that systemic injection of F8-VEGF-C potently reduced edema and inflammation by spatially restricted lymphangiogenesis induction and enhanced lymphatic drainage compared to the F8-SIP control injected mice, in which the protein targets the same moiety but is inert [6].