This paper summarizes the molecular characteristics and functions of CD36 and the physiological and pathological roles of CD36 in eye diseases, especially age-related macular degeneration, diabetic retinopathy, glaucoma, subretinal inflammation, retinal neovascularization, keratitis, and corneal neovascularization, in order to identify CD36 as a therapeutic target for the prevention and treatment related eye diseases. Here, CD36 is linked to diabetic retinopathy.