Overall, exosomes from HFD mice primarily affected the adipose phenotype, as expected from the transcriptomic changes (Figure 4G), resulting in secondary hepatic steatosis due to increased circulating NEFA, as previously observed [13], whereas the primary target of SAC exosomes is the liver, favoring GNG and DNL, ultimately resulting in hepatic steatosis. This evidence concerns the gene ADCY10 and Hepatic steatosis.