In colorectal cancer HCT-15 cells, TSAIII treatment was found to induce apoptosis, as demonstrated by the activation of caspase, induction of cleaved-caspase-3, caspase-8, and caspase-9, and decreased expression of Bcl-xL and Bcl-2 [36]. The gene discussed is CASP3; the disease is colorectal cancer.