One of the characteristic features of glioma is immunosuppression in the presence of Tregs in the immunosuppressive glioma microenvironment, which is potentiated by the suppression of APC functions via the expression of immunosuppressive cytokines, such as IL-10 and TGF-β, contributing to the abolition of effector T-cell progression in the murine model host pDCs promoting glioma [93]. This evidence concerns the gene TGFB1 and central nervous system cancer.