Further KEGG analysis of the commonly regulated genes by both DBC1 and BLM showed that the most enriched pathways were associated with oxidative phosphorylation, Huntington’s disease, metabolic pathways, Parkinson’s disease and Alzheimer’s disease, all of which are either aging-related diseases or contribute to aging when their functions are defective (Figure 3C). Here, BLM is linked to early-onset autosomal dominant Alzheimer disease.