The disease progression of AM/AF (as expressed by un-planned re-hospitalisation for AF and un-planned hospitalisation for heart failure) and thrombo-embolic and atherothrombotic events (as expressed by the onset of TIA/ischaemic stroke and ACS) corresponded to the frequency of circulating CD8+PAR1+ T cells at baseline (Figure 6B,C). Here, CD8A is linked to heart failure.