MACROH2A1 and hepatocellular carcinoma: Increased with age and development of liver cirrhosis and HCC, macroH2A1 was found to synergize with chemo-drug 5-aza-deoxycytidine (5-aza-dC) to induce global DNA hypomethylation while retarding 5-aza-dC-induced senescence, which ultimately ablated the anti-proliferation effect of 5-aza-dC on HCC cells in vitro [127].