Furthermore, anti-PD-1 neutralizing antibodies can sensitize senescent cells, especially PD-L1+ senescent cells, to CD8+ T-cell surveillance, and ameliorate the pathogenesis of high-fat-diet-induced non-alcoholic steatohepatitis (NASH) in the mouse model [156]. The gene discussed is CD274; the disease is metabolic dysfunction-associated steatohepatitis.