Yin et al. found that Runt-related transcription factor 2 (RUNX2), with high expression in breast cancer, recruited metastasis-associated 1 (MTA1)/NuRD and the Cullin 4B (CUL4B)-Ring E3 ligase (CRL4B) complex to form a ternary complex. This evidence concerns the gene RUNX2 and breast cancer.