A study in 2009 showed that the conjugated fatty acid α-eleostearic acid (α-ESA) could act as an agonist of PPARγ, upregulating the level of PPARγ mRNA in MCF7 cells, upregulating PPARγ’s DNA binding activity and transcriptional activity, and mediating PPARγ nuclear translocation, thereby reducing MCF7 cell viability and promoting tumor cell apoptosis. The gene discussed is PPARG; the disease is neoplasm.