The capacity of ONNV to modulate CCL2, CXCL8, and CCL5 expressions was next observed essentially at 24 h post infection with a seven-fold increase for CCL2 mRNA levels (3.34 × 10−1 ± 2.43 × 10−1, p < 0.001) versus (4.67 × 10−2 ± 3.30 × 10−2), a 33-fold increase for CXCL8 mRNA levels (2.26 × 10−2 ± 1.33 × 10−2, p < 0.01) versus (6.76 × 10−4 ± 4.90 × 10−4), and a 72-fold increase for CCL5 mRNA levels (5.06 × 10−3± 2.04 × 10−3, p < 0.001) versus (7.02 × 10−5 ± 3.3 × 10−5) in response to ONNV MOI 1 infection. The gene discussed is CCL5; the disease is infection.