First, SC were infected with ONNV at a multiplicity of infection (MOI) 1, 10−1, 10−2, and 10−3 or stimulated with the viral analog PIC 10 μg/mL, ATP 1 mM, TGF-β2 10 ng/mL, or the proinflammatory cytokines IL-1β 10 ng/mL and TNF-α 10 ng/mL. The gene discussed is IL1B; the disease is infection.