By utilizing the tamoxifen-inducible CreERT2-Lox system to generate a whole-kidney GLUT2 knockout mouse strain, the authors demonstrated that exposing these mice and their WT controls to STZ or a high-fat diet (mimicking T1D or T2D, respectively) induces glycosuria, enhances urinary volume, and improves systemic glucose intolerance [38]. The gene discussed is SLC2A2; the disease is type 1 diabetes mellitus.