Haptoglobin (Hp) can form a stable Hb–Hp complex with hemoglobin (Hb), and microglia facilitate hematoma clearance by mediating the uptake of this complex through CD163 receptors [2]; Hb is also found to degrade intracellularly to the heme in hematoma and perihematomal brain tissue. The gene discussed is HP; the disease is hematoma.