CD4 and neoplasm: Similar to how tumor inoculation promoted the HFD-induced reduction in the number of CD4+ T cells in the blood, the number of CD4+ T cells in the tumors was significantly reduced in HFD-fed mice compared to that in CD-fed mice (55.9 vs. 18.2 cells/mg; mean difference 37.7 cells/mg; 95% CI 14.9–60.3 cells/mg; p = 0.006).