Mitochondrial fragmentation was followed by an increase in DRP1 and FIS1 expression in the cerebral cortex of adenine-induced CKD mice with hypercalcemia; however, calcitonin inhibited the development of hypercalcemia and suppressed DRP1/FIS1-mediated mitochondrial fragmentation to attenuate hypercalcemia induced injury [79]. The gene discussed is FIS1; the disease is hypercalcemia disease.