Mice that lack the three primarily hepatic Cyp2b members, Cyp2b9, Cyp2b10, and Cyp2b13 (Cyp2b-null or Cyp2b9/10/13-null) show greater susceptibility to high-fat diet induced obesity coupled with increased steatosis in males [44,57]. Here, CYP2B6 is linked to obesity disorder.