PPARA and obesity due to melanocortin 4 receptor deficiency: In turn, PUFAs mediate adipocyte differentiation, lipid uptake, metabolism, or storage depending on the PPAR activated or tissue involved; non-insulin dependent diabetes and inflammation through HNF4α, and inflammation, diabetes, obesity, pain regulation, and hypertension through multiple other receptors, including GPCRs [6,15,18].