Gene sets related to biological pathways regulating innate and adaptive anti-tumor immune responses, for example, regulation of monocyte chemotaxis, macrophage migration, regulation of natural killer cell chemotaxis, antigen processing and presentation, positive regulation of T helper cytokine production regulation of CD4- and CD8-positive alpha, beta T-cell activation, and positive regulation of IFNγ production, were observed in the treated tumor samples when compared with untreated controls. The gene discussed is CD4; the disease is neoplasm.