In comparison, the editing level of hsa-mir-497_25_A_g was significantly increased in PD-PC samples and the A-to-I edited miR-497-5p dominantly repressed OPA1 and VAPB, which led to significant downregulation of OPA1 and VAPB in PD-PC (Figure 6b). The gene discussed is OPA1; the disease is pachyonychia congenita.