Therefore, decorin is also expected to prevent or regress neovascularization, EMT, and fibrosis in ischemic retinal diseases such as retinopathy of prematurity, proliferative DR, PVR, retinal detachment, and AMD as a TGF-β antagonist [9,11,107,168,172,175]. This evidence concerns the gene TGFB1 and age-related macular degeneration.