Moreover, the GSEA results showed that the PDE2A-related DEGs in clusters were significantly associated with cell proliferation, mitosis and cell cycle (Figure 2C and Supplementary Figure S1(A1–A9)), tumor metastasis (Figure 2D and Supplementary Figure S1(B1,B2)), and immune activation (Figure 2E and Supplementary Figure S1(C1)). Here, PDE2A is linked to neoplasm.