The rs13118928 GG genotype (p = 0.021; OR = 0.51; 95% CI: 0.27–0.97) and the rs13118928–rs1828591 (GG) haplotype (p = 0.04; OR = 0.65; 95% CI: 0.43–0.98) from the Hedgehog-interacting protein (HHIP) gene were associated with a decreased risk of COPD in women exposed to biomass smoke [182]. This evidence concerns the gene HHIP and chronic obstructive pulmonary disease.