TNF and hepatocellular carcinoma: HCC-bearing mice showed a statistically significant higher hippocampal expression level of IL-1r1 at ZT02 (p = 0.04) and ZT14 (p = 0.002) and of TNF-α at all-time points (p = 0.006 at ZT02, p = 0.01 at ZT08; p = 0.006 at ZT14, and p = 0.03 at ZT20) than control-PB mice (Figure 1).