CASP1 and interstitial lung disease: Moreover, we found a significant and statistically significant correlation between neutrophils and caspase-1 activity in the group of patients with ILD associated with SSc (rho = 0.85, p = 0.001, Table 5), so we cannot rule out the participation of different types of inflammasome in the development of lung lesions; nevertheless, the diverse nature of the autoantigens in each of the cases, as well as the innate sensors that recognize them, could determine the composition of the inflammatory infiltrate in the lung.