In addition, IL-1β and IL-18 were two of the elevated cytokines in the progression of ILD in ASSD, suggesting that innate immune sensors play an essential role in the clinical manifestations in ASSD [11]; these two cytokines were described as proteolytic products of caspase-1 after inflammasome activation, a cytosolic multiprotein platform formed after recognizing different stress signals and microbial molecules [12,13]. The gene discussed is CASP1; the disease is interstitial lung disease.